TY  - JOUR
AU  - Lorenz, Kent Arnold
AU  - Yeshurun, Shlomo
AU  - Aziz, Richard
AU  - Ortiz-Delatorre, Julissa
AU  - Bagley, James Robert
AU  - Mor, Merav
AU  - Kern, Marialice
PY  - 2021
DA  - 2021/5/17
TI  - A Handheld Metabolic Device (Lumen) to Measure Fuel Utilization in Healthy Young Adults: Device Validation Study
JO  - Interact J Med Res
SP  - e25371
VL  - 10
IS  - 2
KW  - resting metabolic rate
KW  - Lumen
KW  - ParvoMedics TrueOne 2400
KW  - validation
KW  - respiratory exchange ratio
KW  - metabolism
KW  - fuel utilization
KW  - indirect calorimetry
KW  - breath
KW  - lung
KW  - respiratory
KW  - young adult
KW  - measurement
KW  - testing
AB  - Background: Metabolic carts measure the carbon dioxide (CO2) produced and oxygen consumed by an individual when breathing to assess metabolic fuel usage (carbohydrates versus fats). However, these systems are expensive, time-consuming, and only available in health care laboratory settings. A small handheld device capable of determining metabolic fuel usage via CO2 from exhaled air has been developed. Objective: The aim of this study is to evaluate the validity of a novel handheld device (Lumen) for measuring metabolic fuel utilization in healthy young adults. Methods: Metabolic fuel usage was assessed in healthy participants (n=33; mean age 23.1 years, SD 3.9 years) via respiratory exchange ratio (RER) values obtained from a metabolic cart as well as % CO2 from the Lumen device. Measurements were performed at rest in two conditions: fasting, and after consuming 150 grams of glucose, in order to determine changes in metabolic fuel usage. Reduced major axis regression and simple linear regression were performed to test for agreement between RER and Lumen % CO2. Results: Both RER and Lumen % CO2 significantly increased after glucose intake (P<.001 for both) compared with fasting conditions, by 0.089 and 0.28, respectively. Regression analyses revealed an agreement between the two measurements (F1,63=18.54; P<.001). Conclusions: This study shows the validity of Lumen for detecting changes in metabolic fuel utilization in a comparable manner with a laboratory standard metabolic cart, providing the ability for real-time metabolic information for users under any circumstances. 
SN  - 1929-073X
UR  - https://www.i-jmr.org/2021/2/e25371
UR  - https://doi.org/10.2196/25371
UR  - http://www.ncbi.nlm.nih.gov/pubmed/33870899
DO  - 10.2196/25371
ID  - info:doi/10.2196/25371
ER  -