TY  - JOUR
AU  - Kanai, Masashi
AU  - Miki, Takahiro
AU  - Sakoda, Toshiya
AU  - Hagiwara, Yuta
PY  - 2025
DA  - 2025/1/20
TI  - The Effect of Combining mHealth and Health Professional–Led Intervention for Improving Health-Related Outcomes in Chronic Diseases: Systematic Review and Meta-Analysis
JO  - Interact J Med Res
SP  - e55835
VL  - 14
KW  - mHealth
KW  - systematic reviews
KW  - meta-analysis
KW  - chronic diseases
KW  - global health
KW  - technology
KW  - health care
KW  - interventions
KW  - chronic conditions
KW  - health care professionals
KW  - World Health Organization
KW  - physical activity
KW  - web-based
AB  - Background: Chronic diseases such as diabetes and cardiovascular disease are global health challenges, affecting millions of people worldwide. Traditional health care often falls short in chronic disease management. This has led to the exploration of innovative solutions, such as mobile health (mHealth) technologies. mHealth, which leverages mobile and wireless technologies, has the potential to transform health care delivery by providing continuous, accessible, and personalized care. However, the effectiveness of mHealth, particularly when integrated with traditional health care interventions delivered by professionals, warrants comprehensive investigation. Understanding the combined impact of mHealth and professional-led interventions is critical to maximizing the potential of mHealth to improve patient outcomes and adherence. Objective: This study aims to investigate the effectiveness of combining mHealth and health professional–led intervention for improving health-related outcomes in chronic diseases Methods: This systematic review and meta-analysis focused on randomized controlled trials. We searched Web of Science, CENTRAL, MEDLINE, and CINAHL through July 17, 2023. The study targeted patients aged 18 years and older, experiencing at least 1 chronic condition. The interventions were a combination of mHealth and the use of a health care professional. The comparison groups consisted of participants receiving either general care and follow-up or those using mHealth devices without any health care professional involvement. The outcomes measured in this review included hemoglobin A1c (HbA1c), quality of life (QoL), and physical activity. Results: The study included 26 research papers, encompassing 7360 individuals. Meta-analysis was conducted for HbA1c, QoL, and physical activity. For HbA1c, short-term improvement was significant (standardized mean difference [SMD] –0.43; 95% CI –0.64 to –0.21; I2=69%) and medium term (SMD –0.49; 95% CI –0.49 to –0.09; I2=21%). However, in the long term, the improvement was not significant (SMD –0.23; 95% CI –0.49 to 0.03; I2=88%). For QoL, significant improvements were observed in the short term (SMD –0.23; 95% CI –0.42 to –0.05; I2=62%), and in the medium term (SMD –0.16; 95% CI –0.24 to –0.07; I2=0%). In the long term, however, the improvement was not significant (SMD –0.12; 95% CI –0.41 to 0.16; I2=71%). For physical activity, both subjective (questionnaire) and objective (number of steps) outcomes were analyzed. In the short term, subjective outcomes showed significant improvement (SMD 0.31; 95% CI 0.12-0.50; I2=0%), while objective outcomes did not (SMD 0.11; 95% CI –0.05 to 0.27; I2=0%). Medium- and long-term subjective outcomes showed no significant improvement. Meta-analysis for objective outcomes in the medium and long term was not possible due to insufficient studies. Conclusions: This study confirmed short- and medium-term benefits of mHealth combined with professional interventions for HbA1c, QoL, and short-term physical activity, supporting effective chronic disease management. 
SN  - 1929-073X
UR  - https://www.i-jmr.org/2025/1/e55835
UR  - https://doi.org/10.2196/55835
DO  - 10.2196/55835
ID  - info:doi/10.2196/55835
ER  -