TY  - JOUR
AU  - Luo, Jia-Yuan
AU  - Deng, Yu-Long
AU  - Lu, Shang-Yi
AU  - Chen, Si-Yan
AU  - He, Rong-Quan
AU  - Qin, Di-Yuan
AU  - Chi, Bang-Teng
AU  - Chen, Gang
AU  - Yang, Xia
AU  - Peng, Wei
PY  - 2025
DA  - 2025/2/26
TI  - Current Status and Future Directions of Ferroptosis Research in Breast Cancer: Bibliometric Analysis
JO  - Interact J Med Res
SP  - e66286
VL  - 14
KW  - breast cancer
KW  - ferroptosis
KW  - bibliometric
KW  - malignancy
KW  - cancer studies
KW  - treatment
KW  - bibliometric analysis
KW  - VOSviewer
KW  - China
KW  - United States
KW  - breast carcinoma
KW  - mammary cancer
KW  - strategy
KW  - trends
KW  - bibliography
KW  - review
KW  - disparities
KW  - forecast
KW  - treatment strategies
KW  - advancements
AB  - Background: Ferroptosis, as a novel modality of cell death, holds significant potential in elucidating the pathogenesis and advancing therapeutic strategies for breast cancer. Objective: This study aims to comprehensively analyze current ferroptosis research and future trends, guiding breast cancer research advancements and innovative treatment strategies. Methods: This research used the R package Bibliometrix (Department of Economic and Statistical Sciences at the University of Naples Federico II), VOSviewer (Centre for Science and Technology Studies at Leiden University), and CiteSpace (Drexel University’s College of Information Science and Technology), to conduct a bibliometric analysis of 387 papers on breast cancer and ferroptosis from the Web of Science Core Collection. The analysis covers authors, institutions, journals, countries or regions, publication volumes, citations, and keywords. Results: The number of publications related to this field has surged annually, with China and the United States collaborating closely and leading in output. Sun Yat-sen University stands out among the institutions, while the journal Frontiers in Oncology and the author Efferth T contribute significantly to the field. Highly cited papers within the domain primarily focus on the induction of ferroptosis, protein regulation, and comparisons with other modes of cell death, providing a foundation for breast cancer treatment. Keyword analysis highlights the maturity of glutathione peroxidase 4-related research, with breast cancer subtypes emerging as motor themes and the tumor microenvironment, immunotherapy, and prognostic models identified as basic themes. Furthermore, the application of nanoparticles serves as an additional complement to the basic themes. Conclusions: The current research status in the field of ferroptosis and breast cancer primarily focuses on the exploration of relevant theoretical mechanisms, whereas future trends and mechanisms emphasize the investigation of therapeutic strategies, particularly the clinical application of immunotherapy related to the tumor microenvironment. Nanotherapy has demonstrated significant clinical potential in this domain. Future research directions should deepen the exploration in this field and accelerate the clinical translation of research findings to provide new insights and directions for the innovation and development of breast cancer treatment strategies. 
SN  - 1929-073X
UR  - https://www.i-jmr.org/2025/1/e66286
UR  - https://doi.org/10.2196/66286
DO  - 10.2196/66286
ID  - info:doi/10.2196/66286
ER  -