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Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture

Augmenting Engagement in Decentralized Clinical Trials for Atrial Fibrillation: Development and Implementation of a Programmatic Architecture

Visual representation of the relational agents that were used in the rural trial (Panel A) and metropolitan trial (Panel B) by intervention participants. The trials shared the primary outcome to improve adherence to oral anticoagulation for thromboembolic stroke prevention in individuals with AF, as measured by pharmacy claims data using the proportion of days covered [36] (a validated measure to quantify medication adherence using pharmacy claims) and by participant self-report [35].

Toluwa Daniel Omole, Andrew Mrkva, Danielle Ferry, Erin Shepherd, Jessica Caratelli, Noah Davis, Richmond Akatue, Timothy Bickmore, Michael K Paasche-Orlow, Jared W Magnani

JMIR Cardio 2025;9:e66436

Population-Wide Depression Incidence Forecasting Comparing Autoregressive Integrated Moving Average and Vector Autoregressive Integrated Moving Average to Temporal Fusion Transformers: Longitudinal Observational Study

Population-Wide Depression Incidence Forecasting Comparing Autoregressive Integrated Moving Average and Vector Autoregressive Integrated Moving Average to Temporal Fusion Transformers: Longitudinal Observational Study

(B) Unemployment rate time series for the overall 20 years population and for specific age subgroups. (C) Ten-year sub-timeseries sample set construction: segmenting the 10-year sub-timeseries (one window) according to year-by-year sliding. In the example shown for 2002-2022, there are 12 sliding windows in total. The first 7 years in each sub-timeseries is the training set, the eighth year is the validation set, and the ninth and tenth year are the testing set.

Deliang Yang, Yiyi Tang, Vivien Kin Yi Chan, Qiwen Fang, Sandra Sau Man Chan, Hao Luo, Ian Chi Kei Wong, Huang-Tz Ou, Esther Wai Yin Chan, David Makram Bishai, Yingyao Chen, Martin Knapp, Mark Jit, Dawn Craig, Xue Li

J Med Internet Res 2025;27:e67156

Efficacy of a Self-Guided Internet Intervention With Optional On-Demand Feedback Versus Digital Psychoeducation on Sleep Hygiene for University Students With Insomnia: Randomized Controlled Trial

Efficacy of a Self-Guided Internet Intervention With Optional On-Demand Feedback Versus Digital Psychoeducation on Sleep Hygiene for University Students With Insomnia: Randomized Controlled Trial

However, by the 8-week posttreatment mark, i CBT-I was not superior in reducing insomnia severity compared to digital sleep hygiene psychoeducation. Further research is warranted to identify effective treatment components, particularly within routine care settings, to improve concise i CBT-Is for implementation in stepped-care approaches to address student insomnia.

Anna-Carlotta Zarski, Karina Bernstein, Harald Baumeister, Dirk Lehr, Stella Wernicke, Ann-Marie Küchler, Fanny Kählke, Kai Spiegelhalder, David Daniel Ebert

J Med Internet Res 2025;27:e58024

Physical, Mental, and Health Empowerment Disparities Across Chronic Obstructive Pulmonary Disease, Asthma, and Combined Groups and the Moderating Role of eHealth Literacy: Cross-Sectional Study

Physical, Mental, and Health Empowerment Disparities Across Chronic Obstructive Pulmonary Disease, Asthma, and Combined Groups and the Moderating Role of eHealth Literacy: Cross-Sectional Study

Specifically, participants in the combined COPD-asthma group, when compared with those in asthma and COPD groups, exhibited a lower health-related quality of life (vs asthma: b=–0.15, adjusted P e Health literacy levels significantly moderated the associations between disease groups and all outcomes (all adjusted interaction P values Visualization of e Health literacy moderation on health disparities across disease groups. COPD: chronic obstructive pulmonary disease.

Jiaying Li, Xiaobing Wu, Yibo Wu, Daniel Yee Tak Fong, Yang Song, Siyi Xu, Changhwan Kim, Xiaohong Lin, Vinciya Pandian

J Med Internet Res 2025;27:e70822