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Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial

Early In-Bed Cycle Ergometry With Critically Ill, Mechanically Ventilated Patients: Statistical Analysis Plan for CYCLE (Critical Care Cycling to Improve Lower Extremity Strength), an International, Multicenter, Randomized Clinical Trial

on the spot at the time of screening Persistent therapy exemptions in the first 4 days of mechanical ventilation: Increase in vasopressor/inotrope within the last 2 hours Active myocardial ischemia or unstable/uncontrolled arrhythmia, as determined by the ICU team Mean arterial pressure 110 mm Hg, or as deemed appropriate by the treating team within the last 2 hours Heart rate 140 bpm within the last 2 hours Persistent oxygen saturation (Sp O2) Neuromuscular blocker within the last 4 hours Severe agitation (Richmond

Diane Heels-Ansdell, Laurel Kelly, Heather K O'Grady, Christopher Farley, Julie C Reid, Sue Berney, Amy M Pastva, Karen EA Burns, Frédérick D'Aragon, Margaret S Herridge, Andrew Seely, Jill Rudkowski, Bram Rochwerg, Alison Fox-Robichaud, Ian Ball, Francois Lamontagne, Erick H Duan, Jennifer Tsang, Patrick M Archambault, Avelino C Verceles, John Muscedere, Sangeeta Mehta, Shane W English, Tim Karachi, Karim Serri, Brenda Reeve, Lehana Thabane, Deborah Cook, Michelle E Kho

JMIR Res Protoc 2024;13:e54451