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Predicting Efficacies of Fractional Doses of Vaccines by Using Neutralizing Antibody Levels: Systematic Review and Meta-Analysis

Predicting Efficacies of Fractional Doses of Vaccines by Using Neutralizing Antibody Levels: Systematic Review and Meta-Analysis

The x-axis and y-axis denote the reported mean neutralization levels from phase 1 and 2 trials and the predicted protective efficacies for vaccines or the convalescent cohort, respectively. The gray solid line and shading indicate the best fit and the 95% CIs of the logistic model, respectively. Each dot indicates the predicted efficacy for vaccines (eg, m RNA, protein subunit, viral vector, inactivated, and DNA) or convalescent individuals.

Zhanwei Du, Caifen Liu, Yuan Bai, Lin Wang, Wey Wen Lim, Eric H Y Lau, Benjamin J Cowling

JMIR Public Health Surveill 2024;10:e49812

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