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The lack of dystrophin leads to the progressive degeneration of muscle fibers, which become connective tissue and fat [2]. The worldwide prevalence is approximately 0.5 per 10,000 male individuals for DMD and 1 per 3500 male individuals for BMD [3]. The loss of ambulation occurs at a median age of 12 years, and ventilation starts at about the age of 20 years, making it a disabling disease with severe motor sequelae and respiratory and cardiac problems, with a high cost to health [4].
JMIR Serious Games 2023;11:e48022
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Existing Funding Sources in Degenerative Cervical Myelopathy Research: Scoping Review
degeneration
Interact J Med Res 2022;11(1):e36194
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The lack of dystrophin leads to a progressive degeneration of muscle fibers, which then become connective tissue and fat [2]. Currently, this disease has no cure. The main symptoms are muscle weakness, which progressively leads to a loss of function and independence, and, in advanced stages of the disease, a compromised respiratory system [3]. Functional tests are performed during medical assessments of children with Duchenne muscular dystrophy [4].
JMIR Mhealth Uhealth 2020;8(12):e21576
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