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Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study

Genomic, Proteomic, and Phenotypic Biomarkers of COVID-19 Severity: Protocol for a Retrospective Observational Study

Here, we seek to use multiomics analysis using 2 tissue types (blood and saliva) in combination with comprehensive ECRs and self-reported data to build one of the most extensive pictures yet. The COVID-19 Response Study (COVRES; NCT05548829) aims to carry out an integrated multiomics analysis of factors contributing to host susceptibility to SARS-Co V-2 among a patient cohort of 1000 people from the geographically isolated island of Ireland.

Andrew English, Darren McDaid, Seodhna M Lynch, Joseph McLaughlin, Eamonn Cooper, Benjamin Wingfield, Martin Kelly, Manav Bhavsar, Victoria McGilligan, Rachelle E Irwin, Magda Bucholc, Shu-Dong Zhang, Priyank Shukla, Taranjit Singh Rai, Anthony J Bjourson, Elaine Murray, David S Gibson, Colum Walsh

JMIR Res Protoc 2024;13:e50733