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Large Language Models for Pediatric Differential Diagnoses in Rural Health Care: Multicenter Retrospective Cohort Study Comparing GPT-3 With Pediatrician Performance

Large Language Models for Pediatric Differential Diagnoses in Rural Health Care: Multicenter Retrospective Cohort Study Comparing GPT-3 With Pediatrician Performance

Differential diagnosis in pediatrics presents unique challenges that distinguish it from adult medicine. Young patients often cannot articulate their symptoms clearly, presentations can be atypical, and the range of potential diagnoses varies significantly with age. Recent systematic reviews have shown that diagnostic errors occur in “appreciable amounts” of pediatric encounters, with higher rates in rural and underserved areas [5].

Masab Mansoor, Andrew F Ibrahim, David Grindem, Asad Baig

JMIRx Med 2025;6:e65263