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Skip search results from other journals and go to results- 8 Journal of Medical Internet Research
- 6 JMIR Research Protocols
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According to the 2019 Asian Working Group for Sarcopenia (AWGS) consensus update, the diagnosis of sarcopenia should be based on changes in muscle strength, physical performance, and muscle mass, with case findings leading to a comprehensive assessment and diagnosis in primary care or community preventive settings [8-10].
JMIR Form Res 2025;9:e63928
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Thank you for your reading of our article “A 4-Week Mobile App–Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial” [1]. We are truly gratified that our study has garnered your attention and interest and has sparked meaningful discussion. In response to the points raised by the authors [2], our answers are as follows.
J Med Internet Res 2025;27:e73174
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Dear Editor:
We are writing to share our thoughts on the article “A 4-Week Mobile App–Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial” [1] published in the Journal of Medical Internet Research. This research presents a significant exploration into the rehabilitation of older adults with sarcopenia, comparing a mobile app–based telerehabilitation approach with traditional in-person rehabilitation.
J Med Internet Res 2025;27:e71845
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Age-related muscle wasting and neurodegeneration, clinically presented as sarcopenia and dementia, respectively, are the major drivers of frailty, falls, and disability in older adults worldwide [1]. Sarcopenia is characterized by loss of muscle mass, strength, and function in older adults. Aging is the leading risk factor, but conditions such as chronic diseases, inflammation, sedentarism, and malnutrition promote sarcopenia onset and progression [2].
JMIR Aging 2025;8:e63686
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With advancing age, many people are experiencing sarcopenia. Sarcopenia can be defined as the age-related decline in skeletal muscle mass and function, highlighting the importance of advancing age as a factor of sarcopenia [2]. Sarcopenia is a natural part of the aging process, but its progression can be hastened by several factors, such as inflammation associated with aging (inflammaging), chronic diseases, lack of physical activity, inadequate nutrition, unintentional weight loss, and disuse events [3].
JMIR Form Res 2025;9:e54392
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Sarcopenia is characterized by a substantial reduction in skeletal muscle mass and function. This condition heightens the risk of falls, fractures, and physical disability and is closely linked to a poorer quality of life, as well as increased mortality rates [3,4].
According to a systematic review from 2022, the prevalence of sarcopenia worldwide is estimated to be 8%-36% in individuals under the age of 60 years and 10%-27% in those over 60 years [5].
J Med Internet Res 2025;27:e67846
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According to the AWGS 2019, sarcopenia is defined as a loss of skeletal muscle mass and a loss of muscle strength or physical capacity, while severe sarcopenia is defined as a loss of skeletal muscle mass plus a loss of both muscle strength and physical capacity; moreover, severe sarcopenia is defined as a loss of both muscle strength and physical performance in addition to a loss of skeletal muscle mass.
Interact J Med Res 2024;13:e58038
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Sarcopenia is also an objective indicator of cancer cachexia [12] and is associated with suboptimal surgical postoperative outcomes [13], lower survival [12,14], and toxic counteraction [15-17]. Mortality rates nearly double when sarcopenia is combined with inflammation [18]. Therefore, addressing the serious health issues of older people with sarcopenia is imperative.
JMIR Aging 2024;7:e58175
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Identifying and Estimating Frailty Phenotypes by Vocal Biomarkers: Cross-Sectional Study
Recent research has examined several physical frailty scales with overlapping components and has distinguished these components into 2 groups: energy-based frailty (EBF) and sarcopenia-based frailty (SBF). This indicates that dietary sodium restriction is associated with a significantly increased risk of SBF, suggesting a potential pathway linking dietary sodium restriction, poor appetite, compromised nutritional status, and SBF in older adults.
J Med Internet Res 2024;26:e58466
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This contributes to sarcopenia, a gradual decline in muscle mass, strength, and physical performance that occurs as individuals age [4], as well as frailty, a state of heightened vulnerability due to the decline in the reserve and function of multiple physiological systems [4].
Frailty and sarcopenia are significant concerns globally, profoundly influencing older adults’ physical capabilities, health risks, quality of life, and longevity [5,6].
J Med Internet Res 2024;26:e59468
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