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However, studies that have examined the shift in demographic and clinical characteristics for the Delta variant are currently limited. A devastating second COVID-19 wave occurred in India in 2021, driven by the Delta variant [11,21].
Interact J Med Res 2024;13:e44492
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Recently, conserved pan-variant epitopes across the Alpha, Beta, Gamma, and Epsilon variant spike proteins have been successfully targeted using a neutralizing antibody fragment [33].
JMIR Bioinform Biotech 2022;3(1):e42243
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Concerns regarding the possible lack of effectiveness of a single dose of COVID-19 vaccine arose with the emergence of the Delta variant, a more contagious variant of COVID-19. In Costa Rica, COVID-19 cases caused by the Delta variant increased from 11% of new infections in the last week of June 2021 to 55% of new infections in the first week of August and to 100% in the last week of September 2021 (Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud [INCIENSA], unpublished data).
JMIR Public Health Surveill 2022;8(5):e35054
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First of all, the authors presented an important work about the new UK variant of COVID in Romania [1]. I have the following questions.
In the Methods section, the authors mentioned that “Twenty samples, collected from patients in the cities of Cluj, Craiova and Suceava counties from Romania were selected for analysis, including patients with possible contacts with UK infected individuals.” In the Introduction section, the authors also described the first few possible UK variant cases in Romania.
JMIRx Med 2021;2(3):e32299
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This paper [1] reports the identification and characterization of the SARS-Co V-2 B.1.1.7 variant (the English variant) in North-East Romania and a synopsis of the circulation of this variant in Romania. The manuscript is timely, straightforward, and professionally crafted, and the results are of interest for the characterization of SARS-Co V-2 strains. Such routine surveys are necessary to trace the emergence of new variants of interest and are scarce in Eastern Europe.
JMIRx Med 2021;2(3):e32296
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In the Introduction section, the authors also described the first few possible UK variant cases in Romania.
Are these 20 cases sequenced by authors related to those cases mentioned in the Introduction? If not, can authors provide some details about the subjects' past travel history? For example, did they stay in UK for more than 2 weeks before they traveled to Romania? And when were these samples collected?
JMIRx Med 2021;2(3):e32293
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Emergence of the First Strains of SARS-CoV-2 Lineage B.1.1.7 in Romania: Genomic Analysis
A new SARS-Co V-2 variant, with an N-Y substitution in the 501 position of the spike (S) protein, was detected in the United Kingdom in the fall of 2020. An initial variant of the virus, termed 501 N, with fewer mutations, occurred in late September in Wales, followed by the current variant (VUI-202012/01), giving rise to lineage B.1.1.7, which began to spread rapidly in the United Kingdom and then globally [1].
JMIRx Med 2021;2(3):e28049
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