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Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis

Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis

Suboptimal medication adherence is recognized as an independent risk factor for these adverse outcomes. Studies report irregular medication-taking behaviors in 15.5% to 57.5% of kidney transplant recipients, with adherence annually declining by 4.8% after transplantation [4,5]. Poor adherence correlates with a 7-fold increased risk of graft failure, a 3-fold higher risk of mortality and exacerbated health care costs [6].

Lili Zhou, Ke Cheng, Linbin Chen, Xinyi Hou, Jingjing Wan

J Med Internet Res 2025;27:e73520

Performance of 3 Conversational Generative Artificial Intelligence Models for Computing Maximum Safe Doses of Local Anesthetics: Comparative Analysis

Performance of 3 Conversational Generative Artificial Intelligence Models for Computing Maximum Safe Doses of Local Anesthetics: Comparative Analysis

The optimal dosing of LAs is complex, influenced by a variety of factors including patient-specific characteristics, underlying health conditions, and potential drug interactions [13]. Current methods for LA dose calculation rely heavily on empirical guidelines and clinician expertise, with no standardized recommendations universally adopted [14]. While several mobile apps exist for LA dose calculation, most allow the computation of potentially unsafe doses.

Mélanie Suppan, Pietro Elias Fubini, Alexandra Stefani, Mia Gisselbaek, Caroline Flora Samer, Georges Louis Savoldelli

JMIR AI 2025;4:e66796

Analyzing Usage of the Metaverse by Associations of Patients With Prostate Cancer During the 2023 Blue Ribbon Campaign: Cross-Sectional Survey Study

Analyzing Usage of the Metaverse by Associations of Patients With Prostate Cancer During the 2023 Blue Ribbon Campaign: Cross-Sectional Survey Study

Further analysis of each subcategory revealed that the item regarding the benefit of gaining information about prostate cancer received the highest agreement within the educational aspect (mean 4.25, SD 0.716), whereas the item concerning the smooth progression of the event received relatively lower agreement (mean 4.01, SD 0.818).

Jung Ki Jo, Yeeun Kim, Yun-Sok Ha, Kwang Taek Kim, Sangjun Yoo, Woo Suk Choi, Jihye Yang, Jaeeun Shin, Sun Il Kim, Jeong Hyun Kim

J Med Internet Res 2025;27:e63030

Shifting Narratives in Media Coverage Across a Decade of Drug Discourse in the Philadelphia Inquirer: Qualitative Sentiment Analysis

Shifting Narratives in Media Coverage Across a Decade of Drug Discourse in the Philadelphia Inquirer: Qualitative Sentiment Analysis

Harm reduction, a public health strategy, seeks to mitigate the adverse effects of drug use without mandating complete cessation [20]. However, media coverage often lacks a comprehensive view of this approach. A study on Canadian news outlets revealed a tendency to focus on singular, controversial harm reduction strategies [21].

Layla Bouzoubaa, Ramtin Ehsani, Preetha Chatterjee, Rezvaneh Rezapour

JMIR Infodemiology 2025;5:e56004

Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Clinical Efficacy and Safety of the Herbal Prescription, HH333, in Preventing Recurrent Stroke in Patients With Ischemic Stroke Induced by Small-Vessel Disease: Protocol for Multicenter, Double-Blind, Randomized, Prospective, Pilot Clinical Trial

Visiting on a day other than the original visit schedule due to an adverse event, etc. c Screening performed within 14 days of informed consent. d Age, sex, smoking, and alcohol history. e Within 1 year prior to visit 0. f Time of first onset and diagnosis (including year, month, and day if possible), date of computed tomography or magnetic resonance imaging, ischemic stroke territory, Trial of Org 10172 in Acute Stroke Treatment classification, history of stroke-related surgery, stroke risk factors, and stroke-related

Han-Gyul Lee, Seungwon Kwon, Woo-Sang Jung, Sang-Kwan Moon, Cheol-Hyun Kim, Dong-Jun Choi

JMIR Res Protoc 2025;14:e70953

Evaluating the Efficacy and Safety of 48-Week Low-Dose Dienogest Administration in Patients With Dysmenorrhea Caused by Endometriosis: Protocol for a Randomized, Open-Label, Parallel-Group Trial

Evaluating the Efficacy and Safety of 48-Week Low-Dose Dienogest Administration in Patients With Dysmenorrhea Caused by Endometriosis: Protocol for a Randomized, Open-Label, Parallel-Group Trial

In particular, we focus on the incidence of adverse effects related to estrogen suppression and the potential for improved treatment adherence with lower doses. Clarifying the dose-dependent relationship between pain relief and adverse effects may help to individualize hormonal therapy strategies for endometriosis.

Kyoko Kikuno, Ryuta Asada, Takuma Ishihara, Yoshimasa Bomoto, Saki Murase, Yoko Ueda, Tomomi Shiga, Yoh Hayasaki, Tatsuro Furui, Satoko Matsuzaki, Masahiko Takemura, Kazutoshi Matsunami, Makoto Kubo, Naoki Ito, Masanori Isobe, Ken-ichirou Morishige

JMIR Res Protoc 2025;14:e66246

Advancing the Use of Longitudinal Electronic Health Records: Tutorial for Uncovering Real-World Evidence in Chronic Disease Outcomes

Advancing the Use of Longitudinal Electronic Health Records: Tutorial for Uncovering Real-World Evidence in Chronic Disease Outcomes

A relapse event is defined either clinically, based on persistent neurological symptoms lasting for more than 24 hours, or radiologically, based on new or enlarged white matter lesions on magnetic resonance imaging (MRI) [9]. It is coded as a binary disease outcome, with “1” indicating a relapse event and “0” indicating no relapse event.

Feiqing Huang, Jue Hou, Ningxuan Zhou, Kimberly Greco, Chenyu Lin, Sara Morini Sweet, Jun Wen, Lechen Shen, Nicolas Gonzalez, Sinian Zhang, Katherine P Liao, Tianrun Cai, Zongqi Xia, Florence T Bourgeois, Tianxi Cai

J Med Internet Res 2025;27:e71873

Nonpharmacological Multimodal Interventions for Cognitive Functions in Older Adults With Mild Cognitive Impairment: Scoping Review

Nonpharmacological Multimodal Interventions for Cognitive Functions in Older Adults With Mild Cognitive Impairment: Scoping Review

older adults with MCI Control: received at least one or multiple forms of an intervention, a placebo or sham training, health education, or treatment as usual Outcome: must use at least one well-established measurement for testing cognitive outcomes Study design: must be an experimental study (randomized controlled trial or quasi-experimental study) Other: full-text and peer-reviewed study written in English Exclusion criteria Participants: diagnosed with dementia or the cognitive impairment resulted from drug

Raffy Chi-Fung Chan, Joson Hao-Shen Zhou, Yuan Cao, Kenneth Lo, Peter Hiu-Fung Ng, David Ho-Keung Shum, Arnold Yu-Lok Wong

JMIR Aging 2025;8:e70291