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Association Between X/Twitter and Prescribing Behavior During the COVID-19 Pandemic: Retrospective Ecological Study

Association Between X/Twitter and Prescribing Behavior During the COVID-19 Pandemic: Retrospective Ecological Study

(3) On April 5, 2020, the president of the United States promoted the use of hydroxychloroquine for COVID-19 [27]. (4) Then the Center for Disease Control deleted a report of physicians using hydroxychloroquine [3]. (5) The Food and Drug Administration on April 24, 2020, announced to use hydroxychloroquine with caution outside of the hospital or clinical trial secondary to arrhythmias [28]. (6) On May 18, 2020, the president of the United States reported tweets that he is taking hydroxychloroquine to protect

Scott A Helgeson, Rohan M Mudgalkar, Keith A Jacobs, Augustine S Lee, Devang Sanghavi, Pablo Moreno Franco, Ian S Brooks, National COVID Cohort Collaborative (N3C)

JMIR Infodemiology 2024;4:e56675

An Electronic Dashboard to Improve Dosing of Hydroxychloroquine Within the Veterans Health Care System: Time Series Analysis

An Electronic Dashboard to Improve Dosing of Hydroxychloroquine Within the Veterans Health Care System: Time Series Analysis

Hydroxychloroquine (HCQ) is among the most commonly used medications for patients with autoimmune conditions and received special attention in 2020 as a potential treatment for COVID-19, resulting in drug shortages for chronic users [1]. These drug shortages, combined with recent guidelines emphasizing toxicities associated with long-term use, highlighted the issue of prescribing HCQ in appropriate doses. Long-term use of HCQ, especially at higher doses, can cause severe retinal toxicity in some patients.

Anna Montgomery, Gary Tarasovsky, Zara Izadi, Stephen Shiboski, Mary A Whooley, Jo Dana, Iziegbe Ehiorobo, Jennifer Barton, Lori Bennett, Lorinda Chung, Kimberly Reiter, Elizabeth Wahl, Meera Subash, Gabriela Schmajuk

JMIR Med Inform 2023;11:e44455

Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach

Toward Preparing a Knowledge Base to Explore Potential Drugs and Biomedical Entities Related to COVID-19: Automated Computational Approach

Antimalaria drug hydroxychloroquine, which is one of the most talked-about drugs for treating COVID-19, was also found in our mining, albeit with a negative interaction. Our model found it is a negative (ie, ineffective) drug with 64.67% confidence. Additionally, it also revealed that this drug has 111 side effects including anemia, hemorrhage, liver disorder, hepatitis fulminant, cardiomyopathy, and cardiac failure, which makes it a risky option, especially for patients with heart and liver complications.

Junaed Younus Khan, Md Tawkat Islam Khondaker, Iram Tazim Hoque, Hamada R H Al-Absi, Mohammad Saifur Rahman, Reto Guler, Tanvir Alam, M Sohel Rahman

JMIR Med Inform 2020;8(11):e21648

Efficacy of Hydroxychloroquine and Tocilizumab in Patients With COVID-19: Single-Center Retrospective Chart Review

Efficacy of Hydroxychloroquine and Tocilizumab in Patients With COVID-19: Single-Center Retrospective Chart Review

Among others, hydroxychloroquine (HCQ) and the interleukin-6 (IL-6) inhibitor, tocilizumab (TCZ), became popular options to treat COVID-19. There is no concrete evidence supporting their use, and they were widely adopted across the world based on anecdotal data. Our hospital, following the guidelines of its parent enterprise, permitted the use of HCQ in COVID-19 patients who had respiratory insufficiency as indicated by low oxygen saturation.

Sohaib Roomi, Waqas Ullah, Faizan Ahmed, Soban Farooq, Usama Sadiq, Asad Chohan, Munnam Jafar, Maryum Saddique, Shristi Khanal, Robert Watson, Margot Boigon

J Med Internet Res 2020;22(9):e21758

Artificial Intelligence for Rapid Meta-Analysis: Case Study on Ocular Toxicity of Hydroxychloroquine

Artificial Intelligence for Rapid Meta-Analysis: Case Study on Ocular Toxicity of Hydroxychloroquine

Hydroxychloroquine has been available since the 1950s [6] and has been used to treat malaria, lupus erythematosus, and rheumatoid arthritis. Most recently, hydroxychloroquine has been highlighted as a potential intervention to support patients with coronavirus disease (COVID-19). Although the efficacy outcomes of hydroxychloroquine are different in each clinical condition for which it is used, adverse events tend to be consistent.

Matthew Michelson, Tiffany Chow, Neil A Martin, Mike Ross, Amelia Tee Qiao Ying, Steven Minton

J Med Internet Res 2020;22(8):e20007

Dermatologists’ Adherence to the Latest Recommendations for Screening of Hydroxychloroquine Retinopathy in Saudi Arabia: Cross-Sectional Study

Dermatologists’ Adherence to the Latest Recommendations for Screening of Hydroxychloroquine Retinopathy in Saudi Arabia: Cross-Sectional Study

Hydroxychloroquine (HCQ), a chemotherapeutic drug, inhibits the erythrocytic forms of malarial parasites with antiautophagic and immunosuppressive activities. Its main mechanism of action is inhibition of plasmodial heme polymerase [1]. HCQ, mostly used as an antimalarial drug, has been used for the management of inflammatory skin conditions for more than 50 years [2].

Nouf Talal Mleeh, Nujood Abdulwahed Alzahrani, Jehad Osama Hariri, Hatan Hisham Mortada, Mohammed Ridha Algethami

Interact J Med Res 2019;8(4):e15218